Research Profile: Cell-based indicators visualize NO release

Cell-based indicator to visualize picomolar dynamics of nitric oxide release from living cells.

We report a novel cell-based indicator that is able to visualize picomolar dynamics of nitric oxide release from living cells. Cells from a pig kidney-derived cell line (PK15) endogenously express soluble guanylate cyclase (sGC), which is a receptor protein for the selective recognition of NO. Binding of NO by sGC causes the amplified generation of guanosine 3',5'-cyclic monophosphate (cGMP). T...

SycView: Visualize and Profile SystemC Simulations

The design of systems-on-chip requires simulation of highly abstracted models, such as SystemC Transaction Level Models (TLM), in addition to traditional register transfer level models. Due to the growing complexity of products, analyzing and understanding the behavior of the corresponding SystemC platforms becomes itself a challenge. Huge code bases are generally written by multiple authors an...

RNA nanotechnology breakthrough for targeted release of RNA-based drugs using cell-based aptamers

Nucleic acids play different roles besides storing information and proteins coding. For example, single-stranded nucleic acids can fold into complicated structures with capability of molecular detection, catalyzing bioreactions and therapy. The development of RNA-based therapies has been rapidly progressed in the recent years. RNA aptamers are biomolecules with a size of 10 to 50 nm that can be...

User Profile Based Research Paper Recommendation

Recommender Systems (RSs) are software tools and techniques providing suggestions for items to be of use to a user. [1] For a recommender system to be effective, it has to have a comprehensive and appropriately catalogued repository of resources. Also, it has to be accurate in understanding the need of the user, and basically has to correctly profile the user. Ideally, one needs to take into co...

Research output indicators are not productivity indicators